NÕELRAVI TOIMEMEHHANISM
Mitokonder on raku organell, mis toimib raku „jõujaamana“.
Mitokondrites sünteesitakse adenosiintrifosfaati (ATP), mis on organismi kõige tähtsam energiakandja. ATPd kasutatakse organismi talitluseks.
https://et.wikipedia.org/wiki/Tsitraadits%C3%BCkkel
Hiina meditsiinis mõistetakse eluenergia e qi all põhiliselt talitlust.
Qi materiaalseks baasiks võivad olla mitokondrid.
Nõelravi ja hiina taimravi toime on seotud ATPga.
Dr. Wallace: “TCM and western medicine will meet at mitochondria.”
Wallace, D.C. (2008) Mitochondria as Chi. Genetics , 179, 727-735.
https://doi.org/10.1534/genetics.104.91769
The real-time detection of acupuncture-induced extracellular ATP mobilization
in acupoints and exploration of its role in acupuncture analgesia
(2022, China)
This work reveals that needling elicits a transient extracellular ATP (eATP) mobilization
in acupoints, which contributes to initiating AP analgesia.
This study will help us better understand the peripheral mechanism of AP analgesia and guide clinicians to optimize the needle manipulations to improve AP efficacy.
Effect of acupuncture on the energy metabolism of dogs with intervertebral disk disease and cervical disk herniation
(2022, Japan)
https://pmc.ncbi.nlm.nih.gov/articles/PMC10209300/pdf/11259_2022_Article_10051.pdf
https://pubmed.ncbi.nlm.nih.gov/36536227/
Vet Res Commun. 2023 Jun;47(2):879-884.
Acupuncture treatments may activate the citric acid cycle and increase ATP production,followed by improvement of the disease.
Targeting Mitochondrial Homeostasis:
The Role of Acupuncture in Depression Treatment
2023, China
https://pmc.ncbi.nlm.nih.gov/articles/PMC10404048/pdf/ndt-19-1741.pdf
https://pubmed.ncbi.nlm.nih.gov/37546517/
Results: Acupuncture has been found to regulate mitochondrial homeostasis (by modulating mitochondrial autophagy, reducing mitochondrial oxidative stress, inhibiting mitochondrial fission, inducing mitochondrial biogenesis, and maintaining mitochondrial dynamics), alleviate depression-like behavior, and regulate signal pathways and key proteins.
Conclusion: Here, we highlight the role of acupuncture in the treatment of depression.
A comprehensive exploration of the impact of acupuncture on mitochondrial homeostasis could potentially present a novel mechanism for treating depression and offer fresh perspectives for the treatment of patients with clinical depression
The Effect of TCM Herbs on Mitochondrial Functions:
The Linkage between Qi and Mitochondria
(2020 China, USA)
https://www.scirp.org/journal/paperinformation?paperid=106653
Studies conducted by Ko et al. have shown that the Yang-invigorating and Yin-invigorating herbs have different impacts on mitochondrial function, with Yang-herbs enhancing ATP generation, and Yin-herbs increasing the immunomodulatory function of cells (2003-2011).
The linkage between mitochondria and Qi/Chi was first introduced by Dr. Wallace,
who proposed that TCM herbs would cure mitochondria related diseases.
The function of mitochondria is similar to that of qi. When the disorder of qi and mitochondria occurs, similar vital signs occur or the same reactions occur.
These results suggested that the basic material attribute of qi might be mitochondria.
Expounding the functions of qi in TCM based on the effect mitochondria
(2014, China)
https://pubmed.ncbi.nlm.nih.gov/25223169/
The function of mitochondria is similar to that of qi.
When the disorder of qi and mitochondria occurs,
similar vital signs occur or the same reactions occur.
These results suggested that the basic material attribute of qi might be mitochondria.
Mast cell-nerve cell interaction at acupoint:
modeling mechanotransduction pathway induced by acupuncture
(2014, China)
https://pmc.ncbi.nlm.nih.gov/articles/PMC4046878/pdf/ijbsv10p0511.pdf
https://www.ncbi.nlm.nih.gov/pubmed/24910530
The results showed mechanical stimuli lead to a intracellular Ca(2+) rise in the mast cell and ATP release, ATP diffuses in the extracellular space (ECS) and activates the nearby nerve cells, then induces electrical current in the nerve cell which spreads in the neural network.
This study may facilitate our understanding of the mechanotransduction process induced by acupuncture and provide a methodology for quantitatively analyzing acupuncture treatment.
Revealing the magic of acupuncture based on biological mechanisms
(2022, China)
BioScience Trends. 2022; 16(1):73-90.
https://www.jstage.jst.go.jp/article/bst/16/1/16_2022.01039/_pdf/-char/en
https://pubmed.ncbi.nlm.nih.gov/35153276/
Stimulated oxygen transport in tissue by magnetic needles
– Physiology of acupuncture
(2022; China, Sweden Uppsala University)
https://www.biorxiv.org/content/10.1101/2021.02.01.426016v2.full.pdf
MERIDIAANID, NÕELRAVIPUNKTID
In Vivo Visualization of the Pericardium Meridian with Fluorescent Dyes
(2021; China, Israel, USA Harvard Medical School)
https://pmc.ncbi.nlm.nih.gov/articles/PMC8021474/pdf/ECAM2021-5581227.pdf
https://pubmed.ncbi.nlm.nih.gov/33854554/
Optical Properties of Acupunctural Points as Diagnostic Method
(2009, Serbia)
http://przyrbwn.icm.edu.pl/APP/PDF/116/a116z475.pdf
Nõelravipunktist algav inimese interstitsiaalse vedeliku ringe võrgustik
An acupoint-originated human interstitial fluid circulatory network
(2021; China, Austria, Germany)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509956/pdf/cm9-134-2365.pdf
Nõelravipunktid ja meridiaanid ning interstitsiaalse vedeliku ringe
An insight into acupoints and meridians in human body based on interstitial fluid circulation
(2020, China)
https://arxiv.org/ftp/arxiv/papers/2012/2012.13593.pdf